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DNA-DNA and DNA-protein crosslinking and repair inNeurospora crassafollowing exposure to nitrogen mustard

Authors
Journal
Mutation Research/DNA Repair Reports
0167-8817
Publisher
Elsevier
Publication Date
Volume
132
Identifiers
DOI: 10.1016/0167-8817(84)90035-x
Keywords
  • Enu Ethyl Nitrosourea
  • Hn2
  • Mnu
Disciplines
  • Biology

Abstract

Abstract A new method was developed for the analysis of DNA-protein crosslinks in Neurospora crassa. The formations of DNA-protein and DNA-DNA crosslinks were assayed following exposure of spheroplasts to HN2. Both types of crosslink were detected and were found to be repaired during recovery. Moreover a mutant sensitive to HN2 was defective in the removal of both types of crosslink.

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