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Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells

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BioMed Central
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PMC
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  • Research Article

Abstract

ar1217.fm Available online http://arthritis-research.com/content/6/6/R544 Open AccessVol 6 No 6Research article Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells Kutty Selva Nandakumar, Johan Bäcklund, Mikael Vestberg and Rikard Holmdahl Section for Medical Inflammation Research, Lund University, Sweden Corresponding author: Kutty Selva Nandakumar, [email protected] Received: 11 May 2004 Revisions requested: 26 May 2004 Revisions received: 16 Jun 2004 Accepted: 30 Jun 2004 Published: 23 Sep 2004 Arthritis Res Ther 2004, 6:R544-R550 (DOI 10.1186/ar1217)http://arthritis-research.com/content/6/6/R544 © 2004 Nandakumar et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited. Abstract Antibodies against type II collagen (anti-CII) are arthritogenic and have a crucial role in the initiation of collagen-induced arthritis. Here, we have determined the dependence of T and B cells in collagen-antibody-induced arthritis (CAIA) during different phases of arthritis. Mice deficient for B and/or T cells were susceptible to the CAIA, showing that the antibodies induce arthritis even in the absence of an adaptive immune system. To determine whether CII-reactive T cells could have a role in enhancing arthritis development at the effector level of arthritis pathogenesis, we established a T cell line reactive with CII. This T cell line was oligoclonal and responded to different post-translational forms of the major CII epitope at position 260–270 bound to the Aq class II molecule. Importantly, it cross- reacted with the mouse peptide although it is bound with lower affinity to the Aq molecule than the corresponding rat peptide. The T cell line coul

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