Affordable Access

Publisher Website

P-glycoprotein expression of the human placenta during pregnancy

Authors
Journal
Placenta
0143-4004
Publisher
Elsevier
Publication Date
Volume
26
Identifiers
DOI: 10.1016/j.placenta.2004.05.013
Disciplines
  • Biology
  • Design

Abstract

Abstract Objective To investigate whether the placental expression of P-glycoprotein shows a quantitative difference during pregnancy. Study design Villous tissue was collected from chorionic villus samples (13–14 weeks of gestation; n=33 and 20–25 weeks of gestation; n=4) and from full-term placentas (38–41 weeks of gestation; n=28). P-glycoprotein was detected by western blot analysis and quantified by densitometry. Results We showed for the first time a significant and progressive two-fold decrease in the mean expression of P-glycoprotein between early and late samples, with a major overlap of values. Conclusion As P-glycoprotein appears to be involved in drug extrusion, these data suggest that the placenta's ability to protect the fetus from xenobiotics is greater in early pregnancy than at term.

There are no comments yet on this publication. Be the first to share your thoughts.