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IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants

Authors
Journal
Cytokine & Growth Factor Reviews
1359-6101
Publisher
Elsevier
Volume
25
Issue
4
Identifiers
DOI: 10.1016/j.cytogfr.2014.07.010
Keywords
  • Il-13Ra2
  • Il-4R Antagonist
  • Cd8 T Cell Avidity
  • Vaccines
  • Infection And Immunity
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The roles of interleukin (IL)-4 and IL-13 during both innate and adaptive Th2 mediated immunity have received considerable scrutiny, however, mechanisms by which these cytokines influence the cellular interactions involved in negatively modulating the development of effective Th1 immunity are poorly characterized. In this article we discuss the recent advances in IL-4/IL-13 biology, mainly (i) role of these cytokines in allergic inflammation, atopic dermatitis, cancer, transplant rejection, bacterial/viral infections, and specifically the therapeutic potential of IL-13Rα2, (ii) insights into how “alarmin” stimulation activate IL-4/IL-13 at the lung mucosae, (iii) how these two cytokines modulate antigen-specific CD8+ T cell quality/avidity in a vaccine route dependent manner and (iv) finally discuss the potential of using transient inhibition of IL-4 and/or IL-13 at the vaccination site as a platform vaccine technology to induce strong sustained high quality CD8+ T cell immunity for protection against many chronic mucosal pathogens such as HIV-1.

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