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Suppressing NFAT Increases VEGF Signaling in Hemangiomas

Authors
Journal
Cancer Cell
1535-6108
Publisher
Elsevier
Publication Date
Volume
14
Issue
6
Identifiers
DOI: 10.1016/j.ccr.2008.11.009

Abstract

Infantile hemangiomas represent the most common tumor of endothelial cell (EC) origin, yet the mechanisms regulating hemangioma EC behavior are poorly understood. A new study by Jinnin et al. demonstrates that enhanced VEGFR2 signaling in hemangioma ECs is caused by suppression of NFAT (nuclear factor of activated T cells)-dependent VEGFR1 expression.

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