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In vitro functional blocking of myelin basic protein-specific cytolytic human T lymphocyte clones by immunosuppressive drugs and monoclonal antibodies

Authors
Journal
Journal of Neuroimmunology
0165-5728
Publisher
Elsevier
Publication Date
Volume
22
Issue
1
Identifiers
DOI: 10.1016/0165-5728(89)90002-7
Keywords
  • Myelin Basic Protein
  • T Cell Clone
  • Interferon-γ
  • Cytotoxicity
  • Prednisolone
  • Cyclosporin A
  • Anti-T Cell Monoclonal Antibody
Disciplines
  • Biology

Abstract

Abstract The in vitro effects of cyclosporin A, prednisolone, and anti-CD4 monoclonal antibody WW.T4 on myelin basic protein-specific human CD4 + cytolytic T lymphocyte clones were studied. Functional assays of antigen-specific proliferation, induction of specific lysis, cytolysis itself, and interferon-γ production were done. Prednisolone decreased secretion of interferon-γ by the clones and blocked specific proliferation; the latter could, however, be overcome by the addition of exogenous interleukin 2. It did not influence cytolytic properties. In contrast, cyclosporin A and WW.T4 blocked the four antigen-specific functions of the autoimmune myelin basic protein-specific T cells clones measured.

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