Abstract A novel current reference based on subthreshold MOSFETs with high power supply rejection ratio (PSRR) is presented. The proposed circuit takes full advantages of the I–V transconductance characteristics of MOSFET operating in the subthreshold region and the enhancement pre-regulator with the high gain negative feedback loop for the current reference core circuit. The proposed circuit, designed with the SMIC 0.18 μm standard CMOS logic process technology, exhibits a stable current of about 1.701 μA with much low temperature coefficient of 2.5×10 −4 μA/°C in the temperature range of −40 to 150 °C at 1.5 V supply voltage, and also achieves a best PSRR over a broad frequency. The PSRR is about −126 dB at dc frequency and remains −92 dB at the frequency higher 1 MHz. The proposed circuit operates stably at the supply voltage higher 1.2 V and has good process compatibility.