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Effect of different parameters on the binding of two anti-inflammatory drugs to human serum albumin

Authors
Journal
Pharmacology Biochemistry and Behavior
0091-3057
Publisher
Elsevier
Publication Date
Volume
24
Issue
4
Identifiers
DOI: 10.1016/0091-3057(86)90452-1
Keywords
  • Human Serum Albumin
  • Indomethacin
  • Indoprofen
  • Anti-Inflammatory Drug Binding
Disciplines
  • Biology
  • Ecology
  • Geography

Abstract

Abstract The binding to human serum albunin of two anti-inflammatory drugs, indomethacin and indoprofen, has been studied by chromatographic and spectroscopic techniques. The results shown indicate that the binding of both drugs—but more notably of indoprofen—is very sensitive to variations of the environmental conditions. The binding is also dependent upon limited modifications in the tertiary structure of the protein. The evidences shown tend to indicate that these two phenomena are related, and that the binding is permitted under conditions of a relatively open structure of the protein molecule.

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