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Anti-brain but not celiac disease antibodies in Landau-Kleffner Syndrome and related epilepsies

Authors
Journal
Journal of Neuroimmunology
0165-5728
Publisher
Elsevier
Publication Date
Volume
160
Identifiers
DOI: 10.1016/j.jneuroim.2004.10.031
Keywords
  • Autoimmunity
  • Pediatric Epilepsy
  • Anti-Brain Autoantibodies
Disciplines
  • Chemistry

Abstract

Abstract The Landau-Kleffner syndrome, the continuous spikes-waves during slow sleep syndrome and the benign epilepsy of childhood with rolandic spikes are rare childhood epilepsies with unknown etiology. Improvement in patients treated with immunoglobulin suggests an involvement of the immune system. We provide immunohistochemical evidence of autoantibodies against rat brain auditory cortex, brainstem and cerebellum, in children suffering with one or more of these syndromes. Only 1/14 patient was celiac.

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