Affordable Access

Publisher Website

Altered chemotactic peptide binding in tobacco smokers' neutrophils

Authors
Journal
Regulatory Peptides
0167-0115
Publisher
Elsevier
Publication Date
Volume
14
Issue
3
Identifiers
DOI: 10.1016/0167-0115(86)90007-8
Keywords
  • Formyl Met-Leu Phe (Fmlp)
  • Polymorphonuclear Leukocytes
  • Tobacco Smoking

Abstract

Abstract The functions of polymorphonuclear leukocytes from tobacco smokers are altered compared to those from nonsmokers. Since neutrophil chemotaxis and oxidative metabolism are mediated by surface receptors, we studied the association of the chemotactic peptide formyl Met-Leu-Phe with neutrophils from smokers and nonsmokers. An apparently single class of binding sites was observed in neutrophils from all the non-smokers, whereas upwardly curving Scatchard plots were obtained for binding to smokers' cells. Thus changes at the receptor level may be responsible for the previously observed alterations in smoker neutrophil function.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Tobacco smokers' neutrophils are desensitized to c...

on Journal of Laboratory and Clin... Jan 01, 1987

Tobacco smokers' neutrophils are desensitized to c...

on Journal of Laboratory and Clin... November 1987
More articles like this..