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How to Assemble a Capsid

Authors
Journal
Cell
0092-8674
Publisher
Elsevier
Publication Date
Volume
131
Issue
1
Identifiers
DOI: 10.1016/j.cell.2007.09.028
Disciplines
  • Biology

Abstract

Retroviral capsids are composed of hexagonal arrays of the viral CA protein. In this issue of Cell, Ganser-Pornillos et al. (2007) provide a molecular model of the hexagonal HIV-1 CA lattice obtained from a new electron cryomicroscopic reconstruction. This study reveals the three principal stabilizing interfaces in the capsid lattice and explains how two different classes of inhibitors can block capsid assembly.

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