Affordable Access

Publisher Website

Formation of 11β-hydroxysteroids requires the integrity of the microfilament network in adrenocortical cells

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
148
Issue
3
Identifiers
DOI: 10.1016/s0006-291x(87)80281-4

Abstract

In order to determine the role of microfilaments in adrenal steroidogenesis, we have studied the effect of cytochalasin B, a microfilament-disrupting agent, on the kinetics of [ 3h]pregnenolone conversion to labelled metabolites by frog interrenal tissue in vitro. Cytochalasin B (5×10 −5M) induced a 50 to 70% decrease in corticosterone, 18-hydroxycorticosterone and aldosterone biosynthesis while the formation of progesterone and 11-desoxycorticosterone was not affected. These result, suggest that microfilaments interfere in the conversion of 11-desoxycorticosterone to corticosterone probably by controlling the movement of ll-desoxycorticosterone from the reticulum to the mitochondria.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Formation of 11 beta-hydroxysteroids requires the...

on Biochemical and Biophysical Re... Nov 13, 1987

Formation of C19 11-hydroxysteroids by porcine Ley...

on Biochemistry and Cell Biology February 1992

INHIBITION OF CELLULAR GROWTH AND STEROID 11β-HYDR...

on Cell Biology International Jan 01, 1996

Differential regulation of 11β-hydroxylase and ald...

on Molecular and Cellular Endocri... Jan 01, 1996
More articles like this..