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The catalytic Friedel–Crafts alkylation reaction of aromatic compounds with benzyl or allyl silyl ethers using Cl2Si(OTf)2or Hf(OTf)4

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
43
Issue
36
Identifiers
DOI: 10.1016/s0040-4039(02)01376-x

Abstract

Abstract The Friedel–Crafts alkylation reaction of various aromatic compounds with benzyl or allyl silyl ethers is effectively promoted under mild reaction conditions using Lewis acid catalysts. A mixture of the desired phenyltolylmethanes is obtained in 80% yield from toluene with benzyl dimethylsilyl or trimethylsilyl ether at 50°C in the presence of a catalytic amount of Cl 2Si(OTf) 2 or Hf(OTf) 4.

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