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Simple and efficient stereological quantitation of some placental structures:A review

Authors
Journal
Placenta
0143-4004
Publisher
Elsevier
Publication Date
Volume
19
Identifiers
DOI: 10.1016/s0143-4004(98)80032-5
Keywords
  • The Maternal-Fetal Interface
Disciplines
  • Design
  • Mathematics

Abstract

Summary This paper provides practical examples of basic stereological methods applied to the human planceta. Systematic random sampling gives all parts the same probability of being represented in the sections obtained for microscopical examination. Isotropy and vertical design are described and formulas provided for calculating volume, surface area, length and number. The importance of counts of particles/cells as a fraction of the reference volume is emphasized, but for unambiguous conclusions, results must be expressed as total quantities. If sampling is correct and optimal, the efficiency of the stereological methods provides unbiased and precise estimates, made from counting no more than about 200 counts in one organ.

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