Affordable Access

Publisher Website

Synthesis of polymeric supports with spacer-modified triazene linkers: aldol and Grignard reactions of immobilized nortropinone

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
44
Issue
12
Identifiers
DOI: 10.1016/s0040-4039(03)00345-9
Keywords
  • Amines
  • Polymer Support
  • Solid-Phase Synthesis
  • Triazenes

Abstract

Abstract Four new polymeric supports with 3- and 6-carbon atom spacers and triazene linkers derived from meta- and para-aminophenol were synthesized from commercial Merrifield polymer. The supports could be used for immobilization of secondary amines in SPOS. A new strategy based on the use of diethylamine triazenes as masked precursors for the generation of polymer-supported diazonium ions was used. The performance of the new linkers was tested on Grignard and aldol reactions of solid-phase immobilized nortropinone. The new supports with C 3-T2 linkers gave products with better yields and purities than the classical T2 supports or the supports with the C 6-T2 linkers.

There are no comments yet on this publication. Be the first to share your thoughts.