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Activation of endothelial nitric oxide synthase following spinal cord injury in mice

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
436
Issue
2
Identifiers
DOI: 10.1016/j.neulet.2008.03.039
Keywords
  • Spinal Cord Injury
  • Endothelial Nitric Oxide Synthase
  • Phosphorylation
Disciplines
  • Chemistry

Abstract

Abstract Endothelial nitric oxide synthase (eNOS) plays a neuroprotective role after cerebral ischemia through the production of NO, which enhances cerebral blood flow. However, precise details regarding activation of eNOS after spinal cord injury (SCI) largely remain to be elucidated. In the present study we investigated chronological alteration and cellular location of eNOS and phosphorylated ( p)-eNOS at Ser 1177 following SCI in mice. Western blot analysis showed eNOS to be significantly phosphorylated at Ser 1177 from 1 to 2 days after mild SCI, with gradual decrease thereafter. Immunohistochemistry revealed the p-eNOS to be mainly expressed in the endothelial cells of microvessels within gray matter under these conditions. These findings suggest that mild SCI activates eNOS in the subacute stage, which increases spinal cord blood flow and may be involved in protective and repair responses.

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