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Development and physiology of signal integration in the DNLL

Authors
Publisher
Ludwig-Maximilians-Universität München
Publication Date
Keywords
  • Graduate School Of Systemic Neurosciences (Gsn)
Disciplines
  • Biology

Abstract

Development and physiology of signal integration in the DNLL DEVELOPMENT AND PHYSIOLOGY OF SIGNAL INTEGRATION IN THE DNLL Julian AMMER Munich, July 2013 Dissertation DEVELOPMENT AND PHYSIOLOGY OF SIGNAL INTEGRATION IN THE DNLL Julian Ammer Graduate School of Systemic Neurosciences Ludwig-Maximilians Universität München Submitted July 2013 First reviewer and supervisor: PD Dr Felix FELMY Second reviewer: Prof Benedikt GROTHE External reviewer: Prof Eckhard FRIAUF Date of oral defense: 21.11.2013 Contents Abstract IV 1 Introduction 1 1.1 Sound localization . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1.1 Interaural level differences . . . . . . . . . . . . . . . . . . 4 1.1.2 Interaural time differences . . . . . . . . . . . . . . . . . . 5 1.1.3 The precedence effect . . . . . . . . . . . . . . . . . . . . 8 1.1.4 Processing of binaural cues in the DNLL . . . . . . . . . . 9 1.1.5 Persistent inhibition alters processing in the inferior colliculus 12 1.2 Motivation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 1.3 Developmental refinement of neuronal circuits . . . . . . . . . . . . 13 1.4 Integration of synaptic inhibition . . . . . . . . . . . . . . . . . . . 16 2 Physiological development of DNLL neurons 20 3 Long lasting inhibition in the DNLL 36 4 Discussion 68 4.1 Implications of fast and precise signaling in the mature DNLL . . . 68 4.2 Synergistic actions as cellular mechanism of persistent inhibition . . 71 4.2.1 NMDA receptor dependent input amplification . . . . . . . 72 II Contents 4.2.2 Synaptic mechanisms . . . . . . . . . . . . . . . . . . . . . 73 4.2.3 Postsynaptic integration . . . . . . . . . . . . . . . . . . . 74 4.3 Persistent inhibition and the precedence effect . . . . . . . . . . . . 77 References 82 Nomenclature 96 Appendix 97 III Abstract The auditory system uses interaural disparities to compute the location of sound sources.

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