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Frizzled signaling and cell–cell interactions in planar polarity

Authors
Journal
Current Opinion in Cell Biology
0955-0674
Publisher
Elsevier
Publication Date
Volume
13
Issue
5
Identifiers
DOI: 10.1016/s0955-0674(00)00263-5
Keywords
  • Cell-To-Cell Contact And Extracellular Matrix
Disciplines
  • Biology

Abstract

Abstract The function of the Frizzled pathway is essential for the formation of the array of distally pointing hairs found on the Drosophila wing. Previous research found that regulating the subcellular location for hair initiation controlled hair polarity. Recent work argues a graded Frizzled-dependent signal results in the accumulation of the Frizzled, Dishevelled and Flamingo proteins along the distal edge of the wing cells. This cortical mark leads to the local activation of downstream gene products and the subsequent activation of the cytoskeleton to form a hair.

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