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Etude des cellules cytotoxiques par hybridationin situet immunohistochimie dans les biopsies musculaires de polymyosites et dermatomyosites

Authors
Journal
La Revue de Médecine Interne
0248-8663
Publisher
Elsevier
Publication Date
Volume
14
Issue
6
Identifiers
DOI: 10.1016/s0248-8663(05)80427-8
Keywords
  • Médecine Interne
Disciplines
  • Biology

Abstract

Cytotoxic cells can kill target cells by secretion of several proteases, serine esterase B (SE-B), perforin (PF) and protein TIA-1. We analysed the presence of cytotoxic cells expressing the SE-B and PF genes by in situ hybridization and expression of TIA-1 by immunohistochimical study from muscular biopsies of 13 patients with inflammatory myopathies; compared to those from 11 subjects control. We found expression of PF in 9 patients, SE-B gene in 10 and liberation of TIA-1 in 12 out of the 13 muscular biopsies tested, supporting the role of cytotoxic cells in pathogeny of inflammatory myopathies.

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