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Endotoxin neutralization and anti-inflammatory effects of tobramycin and ceftazidime in porcine endotoxin shock

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BioMed Central
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PMC
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  • Research
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  • Biology
  • Medicine

Abstract

Available online http://ccforum.com/content/8/1/R35 Research Endotoxin neutralization and anti-inflammatory effects of tobramycin and ceftazidime in porcine endotoxin shock Gunilla Goscinski1, Miklos Lipcsey2, Mats Eriksson3, Anders Larsson4, Eva Tano5 and Jan Sjölin6 1MD, Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden 2MD, Department of Anesthesiology and Intensive Care, Gävle-Sandviken County Hospital, Gävle, Sweden 3Associate Professor, Section of Anesthesiology & Intensive Care, Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden 4Associate Professor, Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden 5Biomedical Scientist, Section of Clinical Microbiology, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden 6Associate Professor, Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden Correspondence: Gunilla Goscinski, [email protected] Introduction Severe Gram-negative infections associated with shock still carry a high mortality rate in spite of appropriate antibiotic treatment and intensive care. Endotoxin, a component of the outer cell wall of Gram-negative bacteria, is a powerful inducer of the systemic inflammatory response that plays an important role in the pathogenesis of septic shock [1]. Anti- biotic treatment represents a key component of treatment for R35 IL = interleukin; LBP = lipopolysacharide-binding protein; MAP = mean arterial pressure; MPAP = mean pulmonary artery pressure; TNF = tumour necrosis factor. Abstract Introduction Antibiotics used for treatment of severe bacterial infections have been shown to exert effects on the inflammatory response in addition to their antibacterial effects. The aim of the present study was to investigate whether the biological effects of endotoxin in a porcine model could be neutralized

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