Affordable Access

Publisher Website

Contribution of Inertial Cavitation in the Enhancement ofIn VitroTransscleral Drug Delivery

Ultrasound in Medicine & Biology
DOI: 10.1016/j.ultrasmedbio.2013.12.032
  • Therapeutic Ultrasound
  • Ocular Drug Delivery
  • Transsclera
  • Sclera
  • Cavitation
  • Design
  • Musicology
  • Physics


Abstract In ocular drug delivery, the sclera is a promising pathway for administering drugs to both the anterior and posterior segments of the eye. Due to the low permeability of the sclera, however, efficient drug delivery is challenging. In this study, pulsed ultrasound (US) was investigated as a potential method for enhancing drug delivery to the eye through the sclera. The permeability of rabbit scleral tissue to a model drug compound, sodium fluorescein, was measured after US-irradiation at 1.1 MHz using time-averaged acoustic powers of 0.5–5.4 W (6.8–12.8 MPa peak negative pressure), with a fixed duty cycle of 2.5% for two different pulse repetition frequencies of 100 and 1000 Hz. Acoustic cavitation activity was measured during exposures using a passive cavitation detector and was used to quantify the level of bubble activity. A correlation between the amount of cavitation activity and the enhancement of scleral permeability was demonstrated with a significant enhancement in permeability of US exposed samples compared to controls. Transmission electron microscopy showed no evidence of significant alteration in viability of tissue exposed to US exposures. A pulsed US protocol designed to maximum cavitation activity may therefore be a viable method for enhancing drug delivery to the eye.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Contribution of Inertial Cavitation in the Enhance...

on Ultrasound in Medicine & Biolo...

A review ofin vitrobioeffects of inertial ultrason...

on Ultrasound in Medicine & Biolo... Jan 01, 1996

Ultrasound-induced cavitation: applications in dru...

on Expert Opinion on Drug Deliver... November 2006

The role of cavitation in acoustically activated d...

on Journal of Controlled Release Oct 03, 2005
More articles like this..