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Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3′ group chirality

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
11
Issue
4
Identifiers
DOI: 10.1016/s0960-894x(00)00719-8

Abstract

Abstract Structure–activity relationships are described for a series of succinyl hydroxamic acids 1a– o and their carboxylic acid analogues 2a– o as inhibitors of matrix metalloproteases MMP-3 and MMP-2. For this series (P1′=(CH 2) 3Ph, P2′= t-Bu) selectivity for the inhibition of MMP-2 was found to be strongly dependent on P3′.

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