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Autonomous cholesterol and fatty acid synthesis in hepatomas: Deletion of the adenosine 3′, 5′-cyclic monophosphate control mechanism of normal liver

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
48
Issue
2
Identifiers
DOI: 10.1016/s0006-291x(72)80059-7

Abstract

Summary Rat hepatoma slices incubated with cAMP (5×10 −3M) or dibutyryl cAMP (3×10 −4M), and acetate-2- 14C, demonstrated unsuppressible cholesterol and fatty acid synthesis, compared to controls. This observation contrasts sharply with that of the marked suppression in lipogenesis brought about by cyclic nucleotides in normal liver and indicates a deletion in hepatomas of this regulatory mechanism in lipogenesis.

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