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Quantitative investigation on Ca++-and pH-dependence of muscle cell fusionin vitro

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
48
Issue
2
Identifiers
DOI: 10.1016/s0006-291x(72)80054-8

Abstract

Summary Muscle cell fusion can be triggered by Ca ++. The curve of fusion percentage vs. [Ca ++] is much steeper than the Langmuir isotherme. The mid point of this curve (representing 50 % fusion) can be shifted from 95 μM to 1100 μM Ca ++ by lowering the pH from 7.6 to 6.3. In the same pH-range the steepness of the curves decreases by a factor of 3. The curves are discussed in terms of a cooperative Ca ++-binding process.

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