In this paper we study and design quasi-2D optomechanical crystals, waveguides, and resonant cavities formed from patterned slabs. Two-dimensional periodicity allows for in-plane pseudo-bandgaps in frequency where resonant optical and mechanical excitations localized to the slab are forbidden. By tailoring the unit cell geometry, we show that it is possible to have a slab crystal with simultaneous optical and mechanical pseudo-bandgaps, and for which optical waveguiding is not compromised. We then use these crystals to design optomechanical cavities in which strongly interacting, co-localized photonic-phononic resonances occur. A resonant cavity structure formed by perturbing a "linear defect" waveguide of optical and acoustic waves in a silicon optomechanical crystal slab is shown to support an optical resonance at wavelength λ_0 ≈ 1.5 μm and a mechanical resonance of frequency ω_m/2π ≈ 9.5 GHz. These resonances, due to the simultaneous pseudo-bandgap of the waveguide structure, are simulated to have optical and mechanical radiation-limited Q-factors greater than 10^7. The optomechanical coupling of the optical and acousticresonances in this cavity due to radiation pressure is also studied, with a quantum conversion rate, corresponding to the scattering rate of a single cavity photon via a single cavity phonon, calculated to be g/2π = 292 kHz.