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Sub-Second Dopamine Detection in Human Striatum

Authors
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
6
Issue
8
Identifiers
DOI: 10.1371/journal.pone.0023291
Keywords
  • Research Article
  • Biology
  • Neuroscience
  • Cognitive Neuroscience
  • Decision Making
  • Neurochemistry
  • Neurochemicals
  • Dopamine
  • Medicine
  • Neurology
  • Parkinson Disease
  • Surgery
  • Neurosurgery
Disciplines
  • Medicine

Abstract

Fast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the feasibility of making sub-second measurements of dopamine release in the caudate nucleus of a human subject during brain surgery. First, we describe the modification of our electrodes that allow for measurements to be made in a human brain. Next, we demonstrate in vitro and in vivo, that our modified electrodes can measure stimulated dopamine release in a rat brain equivalently to previously determined rodent electrodes. Finally, we demonstrate acute measurements of dopamine release in the caudate of a human patient during DBS electrode implantation surgery. The data generated are highly amenable for future work investigating the relationship between dopamine levels and important decision variables in human decision-making tasks.

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