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A-kinase anchoring proteins: scaffolding proteins in the heart.

Authors
Journal
AJP Heart and Circulatory Physiology
0363-6135
Publisher
American Physiological Society
Publication Date
Volume
301
Issue
5
Identifiers
DOI: 10.1152/ajpheart.00569.2011
Keywords
  • A Kinase Anchor Proteins/Metabolism
  • Animals
  • Cardiovascular Agents/Therapeutic Use
  • Cyclic Amp/Metabolism
  • Cyclic Amp-Dependent Protein Kinases/Metabolism
  • Heart Diseases/Drug Therapy
  • Heart Diseases/Enzymology
  • Humans
  • Myocardium/Enzymology
  • Second Messenger Systems/Drug Effects
Disciplines
  • Biology
  • Medicine

Abstract

The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of prolonged catecholaminergic stimulation, cAMP also contributes to the induction of both cardiac myocyte hypertrophy and apoptosis. The formation of localized, multiprotein complexes that contain different combinations of cAMP effectors and regulatory enzymes provides the architectural infrastructure for the specialization of the cAMP signaling network. Scaffolds that bind protein kinase A are called "A-kinase anchoring proteins" (AKAPs). In this review, we discuss recent advances in our understanding of how PKA is compartmentalized within the cardiac myocyte by AKAPs and how AKAP complexes modulate cardiac function in both health and disease.

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