Affordable Access

Publisher Website

mRNA expression pattern of insulin-like growth factor components of granulosa cells and cumulus cells in women with and without polycystic ovary syndrome according to oocyte maturity

Authors
Journal
Fertility and Sterility
0015-0282
Publisher
Elsevier
Publication Date
Volume
94
Issue
6
Identifiers
DOI: 10.1016/j.fertnstert.2010.03.053
Keywords
  • Granulosa Cell
  • Cumulus Cell
  • Igf
  • Igf Receptor
  • Igf Binding Protein
Disciplines
  • Biology

Abstract

The mRNA expression of insulin-like growth factor (IGF) components was investigated in granulosa cells (GCs) and cumulus cells (CCs) sampled from immature and mature follicles in women with and without polycystic ovary syndrome (PCOS). Gene expression for IGF-binding protein (IGFBP) 3 in GCs definitely differed between normal women and women with PCOS, whereas increase in IGF-I and IGF receptor (IGFR) 2 mRNA in mature-follicle GCs, increase in IGF-II, IGFR-1, and IGFBP-4 mRNA in immature-follicle GCs, increase in IGFR-2 and IGFBP-2 mRNA in mature-follicle CCs , and increase IGFBP-6 mRNA in immature-follicle CCs were observed in both normal women and women with PCOS.

There are no comments yet on this publication. Be the first to share your thoughts.