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Acyclic analogs of kainoids: Their syntheses and depolarizing activities

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
52
Issue
6
Identifiers
DOI: 10.1016/0040-4020(95)01058-0

Abstract

Abstract Four stereoisomers of the β-benzylglutamic acids were synthesized by the Michael addition of benzylphenylsulfide to protected (4 S)- and (4 R)- 4-amino-2-penten-5-olide and to protected (2 S)- and (2 R)-3-dehydro-2-hydroxymethyl-5-pyrrolidone. The β-methallyl- and β-isobutylglutamic acids were also synthesized in a similar manner. The depolarizing activities of these synthesized compounds were observed.

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