Affordable Access

Publisher Website

Oxypurinol attenuates ischemia-induced hippocampal damage in the gerbil

Authors
Journal
Brain Research Bulletin
0361-9230
Publisher
Elsevier
Publication Date
Volume
23
Issue
6
Identifiers
DOI: 10.1016/0361-9230(89)90191-3
Keywords
  • Oxypurinol
  • Xanthine Oxidase
  • Hippocampus
  • Motor Activity
  • Stroke Model
  • Neuroprotection
Disciplines
  • Biology

Abstract

Abstract Oxypurinol, an inhibitor of the enzyme xanthine oxidase, reduced ischemic hippocampal damage and the associated hypermotility in Mongolian gerbils. Cerebral ischemia was induced in unanesthetized gerbils by a bilateral 5-min occlusion of the carotid arteries. Oxypurinol (40 mg/kg, IP), administered 20 min prior to carotid occlusion, prevented the increase in locomotor activity observed in saline-injected ischemic animals and significantly reduced the damage to, and loss of, CA1 hippocampal neurons observed 5 days postischemia. These findings suggest that Oxypurinol may be useful for the prevention of cerebral ischemic damage.

There are no comments yet on this publication. Be the first to share your thoughts.