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p66 anin vivotarget for poly(ADP-ribosyl)ation co-purifies with poly(ADP-ribose) polymerase

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
165
Issue
2
Identifiers
DOI: 10.1016/s0006-291x(89)80012-9
Disciplines
  • Biology
  • Design

Abstract

A direct immunoassay has been applied for the quantitation of poly(ADP-ribose) polymerase and its automodification in BALB/3T3 (A31) cells. As the cell population reached a high density, a 66 kDa protein (designated p66) which co-purified with the enzyme became highly poly(ADP-ribosyl)ated. Pulse-chase experiments as well as a Western blot analysis indicated that the p66 was not a degradation product of poly(ADP-ribose) polymerase.

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