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A new highly stereoselective construction of the sidechain of squalamine through improved Sharpless catalytic asymmetric dihydroxylation

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
42
Issue
13
Identifiers
DOI: 10.1016/s0040-4039(01)00191-5
Keywords
  • Methyl-5α-Chenodeoxycholanate
  • Desmosterol Derivative
  • Improved Sharpless Ad
  • Squalamine

Abstract

Abstract A new highly stereoselective construction of the sidechain of squalamine has been achieved by using methyl-3-keto-5α-chenodeoxycholanate ( 2 ) as the starting material and an improved Sharpless catalytic asymmetric dihydroxylation as the key step.

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