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Aromatase and nonaromatizing 10-demethylase activity of adrenal cortex mitochondrialP-45011 β

Authors
Journal
Archives of Biochemistry and Biophysics
0003-9861
Publisher
Elsevier
Publication Date
Volume
267
Issue
1
Identifiers
DOI: 10.1016/0003-9861(88)90004-5
Keywords
  • Oxygenases
  • Microsomes
  • And P450 Reactions
Disciplines
  • Biology

Abstract

Abstract 19-Oxoandrostenedione, the product of 19-hydroxyandrostenedione by the 19-oxidase activity of the purified P-450 11 β system of adrenal cortex mitochondria, was further oxidized and demethylated at the 10-position to give the C 18-steroids, estrone (aromatase reaction) and 19-norandrostenedione (nonaromatizing 10-demethylase or C10–19 lyase reaction). These reactions, together with the initial hydroxylation of androstenedione at C19, form a sequence of P-450 11β-catalyzed C 19-steroid 19-monooxygenase reactions. P-450 11 β is thus similar to placental endoplasmic P-450 AROM in some of its substrate specificity, but the two forms of P-450 appear to be different in both physiology and properties.

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