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HIC1 promoter methylation and 17p13.3 allelic loss in invasive ductal carcinoma of the breast

Authors
Journal
Cancer Letters
0304-3835
Publisher
Elsevier
Publication Date
Volume
222
Issue
1
Identifiers
DOI: 10.1016/j.canlet.2004.08.026
Keywords
  • Breast Cancer
  • Dna Methylation
  • Hic1
  • Tumor Suppressor Genes
  • Chromosome 17P13
  • Loh
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The HIC1 gene is a transcriptional regulator commonly methylated in a variety of human cancer. Thirty-three invasive ductal carcinomas of the breast and 21 matched normal breast tissues were analysed for HIC1 promoter methylation, and allelic loss of a 700 kb region spanning the gene locus. At least one genetic or epigenetic abnormality was found in 27 of the carcinomas tested (82%). Promoter methylation was demonstrated in 21 carcinomas (64%), and nine normal tissues (43%), whereas 18 malignant tumors (54%) showed allelic loss. Concomitant loss of heterozigosity and promoter hypermethylation in the region spanning HIC1 was detected in eight carcinomas (24%) suggesting that in this subset of tumors both copies of the gene are functionally lost. These observations support a role for the HIC1 gene in the pathogenesis of breast ductal carcinomas.

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