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Pharmacology and regulation of the neuronal dopamine transporter

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
324
Issue
1
Identifiers
DOI: 10.1016/s0014-2999(97)00065-4
Keywords
  • Dopamine Transporter
  • Win 35
  • 428 Binding
  • Arachidonic Acid
  • Protein Kinase C
  • Parkinson'S Disease
  • Drug Abuse
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The dopamine transporter, a member of the family of Na +,Cl −-dependent transporters, mediates uptake of dopamine into dopaminergic neurons by an electrogenic, Na +− and Cl −-transport-coupled mechanism. Dopamine and blockers of uptake such as cocaine probably bind to both shared and separate domains on the transporter, which can be influenced dramatically by the presence of cations. Regulation of the dopamine transporter occurs both by chronic occupancy with blocker and by acute effects of D 2 dopamine receptors or second messengers such as diacylglycerol (protein kinase C) and arachidonic acid. The dopamine transporter is involved in the uptake of toxins generating Parkinson's disease; it is also an important target for psychostimulant drugs, ligands for in vivo imaging and medications used for neurologic diseases involving changes in the dopamine system. © 1997 Elsevier Science B.V. All rights reserved.

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