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Origin and function of fluctuations in cell behaviour and the emergence of patterns

Authors
Journal
Seminars in Cell and Developmental Biology
1084-9521
Publisher
Elsevier
Publication Date
Volume
20
Issue
7
Identifiers
DOI: 10.1016/j.semcdb.2009.07.009
Keywords
  • Morphogenesis
  • Cytoskeleton
  • Adhesion
  • Planar Cell Polarity
  • Fluctuations

Abstract

Abstract Morphogenesis is the process whereby cells assemble into tissues and organs. Recent studies of this process have revealed heterogeneity of individual cell behaviours that contrasts with the deterministic activity of tissues as a whole. Here we review these observations and suggest that fluctuations and heterogeneities are a central substrate for morphogenesis and that there might exist mechanisms dedicated to the averaging of these fluctuations to ensure robust and reproducible behaviours at the tissue level.

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