Affordable Access

Publisher Website

Inhibitory histamine H2-receptor in the guinea-pig urinary bladder

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
105
Identifiers
DOI: 10.1016/0014-2999(84)90654-x
Keywords
  • Histamine H2-Receptor
  • Urinary Bladder
  • Cimetidine
  • Impromidine

Abstract

Abstract The histamine H 2-receptor in the guinea-pig urinary bladder was characterized by determining the effects of histamine and impromidine on contractions induced by electrical transmural stimulation (ETS). The contractile responses to ETS (0.5 ms, 15 V, for 15 s) at frequencies of 1 to 30 Hz were abolished by treatment with tetrodotoxin, and were partly inhibited by scopolamine, indicating that the ETS-induced contraction has scopolamine-sensitive and -resistant components. Histamine and impromidine inhibited the scopolamine-resistant contraction induced by ETS but not the ETS-induced scopolamine-sensitive contraction and nicotine- and acetylcholine (ACh)-induced contractions. The inhibitory effects of histamine and impromidine were antagonized by cimetidine, but not by diphenhydramine and mepyramine. Thus, the inhibitory effect of histamine may be mediated through H 2-receptors. As impromidine did not affect the tetrodotoxin-sensitive and Ca 2+-dependent ETS-evoked release of ACh and noradrenaline (NA) from the isolated urinary bladder preloaded with [ 3H]choline and [ 3H]NA, respectively, the H 2-receptor may not be involved in the cholinergic and adrenergic mechanisms. These results indicate that histamine H 2-receptors are present in the guinea-pig urinary bladder. The H 2-receptor located on non-cholinergic excitatory neurons may be involved in the inhibitory action produced by histamine.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Inhibitory histamine H2-receptor in the guinea-pig...

on European Journal of Pharmacolo... Oct 01, 1984

Histamine H1-receptors in the guinea-pig urinary b...

on European Journal of Pharmacolo... Aug 07, 1985

Histamine H1-receptors in the guinea-pig urinary b...

on European Journal of Pharmacolo... Jan 01, 1985

Occurrence of H1- and H2-histamine receptors in th...

on British Journal of Pharmacolog... October 1978
More articles like this..