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A nuclease from animal serum which hydrolyzes double-stranded RNA

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
41
Issue
3
Identifiers
DOI: 10.1016/0006-291x(70)90056-2
Disciplines
  • Biology

Abstract

Abstract Animal serum contains an enzyme which hydrolyzes synthetic and naturally occurring double-stranded RNA's. The entirely base-paired replicative form of an RNA virus (Semliki Forest Virus), the synthetic duplex poly I:poly C, as well as a highly structured RNA from uninfected animal cells were substrates for this enzyme under conditions in which these RNA's were resistant to ribonuclease A.

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