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Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder : (a)functional magnetic resonance imaging study

서울대학교 대학원
Publication Date
  • 외상 후 스트레스 장애
  • Posttraumatic Stress Disorder (Ptsd)
  • 기능성 자기공명영상
  • Functional Magnetic Resonance Imaging (Fmri)
  • 전대상회
  • Anterior Cingulate
  • 불안
  • Anxiety
  • 공포
  • Fear
  • 외상
  • Trauma
  • Biology
  • Medicine


Posttraumatic stress disorder (PTSD) is characterized by re-experiencing symptoms, persistent avoidance of stimuli associated with the traumatic event, and symptoms of arousal that were not present before the traumatic event. Previous brain imaging studies have consistently reported hyperactivation of the amygdala and hypoactivation of the anterior cingulate in PTSD patients, which is believed to be the underlying neural mechanism of the PTSD symptoms. The current thesis focuses on these functional abnormalities and its relevance to PTSD symptoms, in order to clarify the psychopathology of PTSD. The current experiment specifically focuses on the abnormal functioning of the rostral anterior cingulate, using a paradigm which elicits unexpected processing conflict caused by salient emotional stimuli. For this study, twelve survivors (seven men and five women) of the Taegu subway fire in February, 2003, who later developed PTSD agreed to participate in this study. Twelve healthy volunteers (seven men and five women) were recruited for comparison. Functional brain images of all PTSD patients and healthy subjects were acquired using functional magnetic resonance imaging (fMRI) while performing a same-different judgment task, which was modified to elicit unexpected emotional processing conflict. Additionally, PTSD patients were assessed of their symptoms by using Clinician Administered PTSD Scale (CAPS), Impact of Event Scale-Revised (IES-R), Hamilton Anxiety Rating Scale (HARS), and Hamilton Depression Rating Scale (HDRS). The results show decreased rostral anterior cingulate functioning in PTSD patients compared to healthy subjects, when exposed to situations which induce unexpected emotional processing conflict. Moreover, PTSD symptom severity was negatively correlated to the level of decrease in rostral anterior cingulate activity. Also, PTSD patients showed decreased response in the fronto-striatal system during the task, which are f

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