Prenatal exposure of Ncholinolytic gangleron compared with Mcholinolytic methamyzil to pregnant rat females at 9–19 days of pregnancy produced the longterm behavioral changes in pubescent rat progenies. Pubescent rat progenies had got the low dynamics of gaining sexual experience and decreased sexual activity with equal disturbance of motivation and coitus. The quantity of males with reduced sexual activity was more compared with the control group. It is suggested that sexual dysfunction of adulthood offsprings is provoked by introduction of gangleron (Ncholinolytic) which was injected at 9–11 and 12–14 days of gestation, and methamyzil (Mcholinolytic) injected at 9–11 days of gestation. We suppose that the regulation of neuronal mechanisms for sexual function is disturbed as a consequence of longterm changings in neurotransmitter activity (first of all in the dopaminergic activity) in the hippocampus and hypothalamus. Therefore, in brain limbic structures was mostly affected. The second reason of the reduced sexual activity in the offsprings is the decrease of the blood testosterone.