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How do NK cells sense the expression of HLA-G class Ib molecules?

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
9
Issue
1
Identifiers
DOI: 10.1006/scbi.1998.0107
Keywords
  • Cd94
  • Hla-E
  • Hla-G
  • Nk Cell
  • Trophoblast

Abstract

Abstract The nature of NK cell receptors involved in recognition of HLA-G1 has remained an unclear issue; we herein review this topic based on our experience. We found no evidence that well characterized p58 and p70 KIRs may interact with HLA-G1. By contrast, our data support that NK recognition of cells expressing HLA-G1 involves at least two non-overlapping receptor–ligand systems: (1) the direct engagement of the ILT2 (LIR1) receptor by HLA-G1; and (2) the interaction of CD94/NKG2A and CD94/NKG2C receptors with the non-classical class I molecule HLA-E, co-expressed on the surface upon binding to a nonamer (VMAPRTLFL) from the HLA-G leader sequence.

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