Affordable Access

HLA antigens in donovanosis (granuloma inguinale).

Publication Date
  • Research Article
  • Medicine


OBJECTIVE--To compare the frequencies of HLA antigens in patients with donovanosis and in controls. DESIGN--HLA Class I, Class II and DQ antigens were detected in patients with genital ulceration caused by donovanosis and in a control group. SETTING--City Health STD Clinic, King Edward VIII Hospital, Durban, South Africa. Participants--Sixty (47 men, 13 women) patients with donovanosis. RESULTS--HLA B57 was detected in nine of 60 (15%) with donovanosis and 75 of 1478 (5.1%) controls (RR = 3.3 chi 2 = 11.0, p = 0.001, p corrected = 0.026). CONCLUSIONS--A possible link between donovanosis and HLA B57 could be explained by coexisting alleles or immune response genes in linkage disequilibrium altering disease susceptibility.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

HLA antigens in donovanosis (granuloma inguinale).

on Genitourinary medicine October 1991

Granuloma inguinale (donovanosis) in women.

on The Journal of reproductive me... August 1988

Donovanosis (granuloma inguinale) in pregnancy.

on International Journal of STD &... 1991

Granuloma inguinale (donovanosis) in South Africa.

on South African medical journal... Apr 16, 1983
More articles like this..