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Adapter and enzymatic functions of proteases in T-cell activation.

Authors
Journal
Immunological Reviews
0105-2896
Publisher
Wiley Blackwell (Blackwell Publishing)
Publication Date
Volume
232
Issue
1
Identifiers
DOI: 10.1111/j.1600-065x.2009.00830.x
Disciplines
  • Biology
  • Medicine

Abstract

Proteases control many vital aspects of humoral and cellular immune responses, including the maturation of cytokines and the killing of target cells. Recently, it has become evident that triggering of the T-cell receptor controls T-cell proliferation through proteases such as mucosa-associated lymphoid tissue 1 (MALT1) and Caspase-8 that act both as adapters and enzymes. Here, we discuss the role of these and other proteases that are relevant to the control of the T-cell response and represent interesting targets of therapeutic immunomodulation.

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