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Glycosylation with highly reactive glycosyl donors: efficiency of the inverse procedure

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
32
Issue
28
Identifiers
DOI: 10.1016/s0040-4039(00)92704-7

Abstract

Abstract α-Fucosylation with the reactive trichloroacetimidate 1 as donor and disaccharides 2 and 4 as acceptors led to a remarkable increase in yield under “inverse conditions”, i.e. addition of the donor to an acceptor/catalyst solution. Thus, acceptor/catalyst complex formation enforcing, the generation of the glycosylating species in the vicinity of the acceptor is favored yielding building blocks for antigen determinant synthesis

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