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Steroidogenic capabilities of the early mouse embryo

Authors
Journal
Steroids
0039-128X
Publisher
Elsevier
Publication Date
Volume
32
Issue
3
Identifiers
DOI: 10.1016/0039-128x(78)90086-7

Abstract

Abstract Preimplantation embryos from ICR albino mice were used to determine progesterone and estradiol-17β production during incubation in BMOC-2. Following culture of 40 embryos/culture at either the morula, early blastocyst or late blastocyst stages, progesterone and estradiol-17β contents were 192±27 and 82±22 pg, 289±50 and 147±46 pg and 157±28 and 88±23 pg, respectively, for incubated samples and 306±68 and 89±40 pg, 404±63 and 125±44 pg, and 241±54 and 86±39 pg, respectively for control samples. Although, there were significant stage of development and treatments effects ( P<0.05) for progesterone, production of this steroid was not evident. These data suggest that the early preimplantation mouse embryo does not produce progesterone or estradiol-17β in a defined culture system.

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