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Potential impact of human mitochondrial replacement on global policy regarding germline gene modificationImpact of mitochondrial replacement on global policy

Authors
Journal
Reproductive BioMedicine Online
1472-6483
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.rbmo.2014.04.001
Keywords
  • Enhancement
  • Ethics
  • Eugenics
  • Genome-Editing Technology
  • International Harmonization
  • Ivf
Disciplines
  • Law
  • Medicine
  • Philosophy

Abstract

Abstract Previous discussions regarding human germline gene modification led to a global consensus that no germline should undergo genetic modification. However, the UK Human Fertilisation and Embryology Authority, having conducted at the UK Government’s request a scientific review and a wide public consultation, provided advice to the Government on the pros and cons of Parliament’s lifting a ban on altering mitochondrial DNA content of human oocytes and embryos, so as to permit the prevention of maternal transmission of mitochondrial diseases. In this commentary, relevant ethical and biomedical issues are examined and requirements for proceeding with this novel procedure are suggested. Additionally, potentially significant impacts of the UK legalization on global policy concerning germline gene modification are discussed in the context of recent advances in genome-editing technology. It is concluded that international harmonization is needed, as well as further ethical and practical consideration, prior to the legalization of human mitochondrial replacement.

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