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Design of simulated moving bed processes under reduced purity requirements

Authors
Journal
Journal of Chromatography A
0021-9673
Publisher
Elsevier
Publication Date
Volume
1162
Issue
1
Identifiers
DOI: 10.1016/j.chroma.2007.02.063
Keywords
  • Simulated Moving Bed
  • True Moving Bed
  • Design Method
  • Reduced Purity
  • Equilibrium Theory
  • Langmuir Adsorption Isotherm
Disciplines
  • Design

Abstract

Abstract The design of simulated moving bed chromatography under reduced purity requirements is investigated. A parametric study indicates that all internal flow rates should be considered as free parameters in process design. This is confirmed by systematic numerical optimisations of two different design scenarios. A restrictive scenario requires complete regeneration of liquid and solid phases. In contrast, in a non-restrictive design all flow rates are optimised. The latter leads to significantly improved process performance. On the basis of the obtained observations, a simple design method for simulated moving bed processes with desired outlet purity values is derived from equilibrium theory.

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