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Synthesis of RPR 100893, prototype of a new series of potent and selective non peptide NK1 antagonists : the triarylperhydroisoindolols.

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
4
Issue
5
Identifiers
DOI: 10.1016/s0960-894x(01)80178-5

Abstract

Abstract The synthesis of enentiomerically pure RPR 100893, a novel non peptide NK1 Substance P antagonist, is described. This compound is a representative of 7,7,4-triaryl perhydroisoindol-4-ols, a new series of perhydroisoindole Substance P antagonists with high affinity for human NK 1 receptor.

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