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Restriction of the Mobility of Lymphocyte Immunoglobulin Receptors by Concanavalin A

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PMC
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  • Biological Sciences: Cell Biology

Abstract

The induction by anti-immunoglobulin of patch and cap formation on mouse lymphocytes was inhibited by the addition of concanavalin A. This effect was reversed by α-methyl-D-mannoside, a competitive inhibitor of the binding of concanavalin A. Concanavalin A prevented both patch and cap formation, in contrast to the metabolic inhibitor NaN3, which prevented only cap formation. This suggests that binding of concanavalin A induces changes on or in the lymphocyte membrane that inhibit free diffusion of immunoglobulin receptors.

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