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Short- and long-term immunogenicity and protection induced by non-replicating smallpox vaccine candidates in mice and comparison with the traditional 1st generation vaccine

Authors
Journal
Vaccine
0264-410X
Publisher
Elsevier
Publication Date
Volume
26
Issue
14
Identifiers
DOI: 10.1016/j.vaccine.2007.12.059
Keywords
  • Smallpox Vaccine
  • Vaccine Immunogenicity
  • Vaccine Protection
  • Modified Vaccinia Ankara
  • Vaccinia Virus
Disciplines
  • Medicine

Abstract

Summary This study assessed three non-replicating smallpox vaccine candidates (modified vaccinia Ankara (MVA), NYVAC and HR) for their immunogenicity and ability to protect mice against an intranasal cowpox virus challenge and compared them with the traditional replicating vaccine. A single immunisation with the non-replicating vaccines induced a complete protection from death at short-term, but was not fully protective when mice were challenged 150 days post-vaccination with protection correlated with the specific neutralizing antibodies and CD4 + T-cells responses. Prime-boost vaccination enabled effective long-term protection from death for mice vaccinated with MVA, but protection from disease and CD4 + T-cell level were lower than the ones induced by the traditional vaccine over the long-term period. Further investigations are necessary with MVA to determine the optimal conditions of immunisation to induce at long-term immunogenicity and protection observed with the 1st generation smallpox vaccine.

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